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doi: 10.1126/science.1076781
In summary, metformin disrupts the normal proliferation process of glioma cells and triggers apoptosis by activating the AMPK/mTOR signaling pathway, cell cycle arrest, mitochondria-dependent apoptosis pathway, inhibition of tumor cell metabolism, oxidative stress, and DNA damage, which provides a new idea for the treatment of glioma
Single daily dosing at higher doses (500+ mcg) is not recommended for recovery research
Metabolites 10 , 231 (2020)
