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A mitochondria-targeted covalent organic framework (COF) prodrug that is selectively activated by high intramitochondrial GSH levels was shown to trigger catalase collapse within the organelle, thereby amplifying local chemodynamic therapy (CDT) through enhanced ROS accumulation and mitochondrial dysfunction

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Muscle Growth and Hypertrophy IGF1 LR3 directly activates satellite cells , which are muscle stem cells responsible for repairing and building new muscle fibers