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Larazotide: Closing the Gaps in Leaky Gut and Irritable Bowel Syndrome What is Larazotide

Recent microbiome studies revealed that anti-inflammatory commensals such as Akkermansia muciniphila and Faecalibacterium prausnitzii are significantly reduced in HT patients, correlating with higher TPOAb titers and disease activity (Xie et al

Table 3)

Figure 2: Changes in body weight from baseline to the end of treatment at week 26 associated with the treatment policy estimand, in the randomly assigned treatment groups administered either 0.3 mg of cagrilintide, 0.6 mg of cagrilintide, 1.2 mg of cagrilintide, 2.5 mg of cagrilintide, 4.5 mg of cagrilintide, 3.0 mg of liraglutide, or a placebo