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Seek urgent care for breathing difficulty, facial/lip/tongue/throat swelling, severe allergic symptoms, or rapidly worsening infection signs
Maggiora G
Journal of Investigative Dermatology, 130(Suppl 1), S45

These pain-relieving effects are blocked by drugs that affect norepinephrine, but not serotonin, suggesting that the pain relief works through adrenergic pathways (9)
