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The absence of predefined filters or restrictions during the identification of included studies was intentional, ensuring a comprehensive and unbiased search strategy

Histological examination was performed by blind method for cartilage damage, synovial hypertrophy and changes in inflammatory cell infiltration, and graded from 03 as previously described (Helyes et al., 2004

Beyond CMH detection, our high-throughput machine learning-driven imaging pipeline can be adapted to analyze additional histological markers of microvascular pathology