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It is notable that the GSH-induced airway changes in the third challenge were of lesser magnitude than in the other two, possibly because airway tone was conditioned by the previous nebulization with placebo, although changes in the degree of bronchial hyperresponsiveness by itself through the whole study also could play a role

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PMID: 39891996, PMCID: PMC11840234, DOI: 10.1016/j.ebiom.2025.105578

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