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Supplementary Materials Data Availability Statement No new data were created or analyzed in this study
The SPS3 trial (Secondary Prevention of Small Subcortical Strokes) recruited 3020 patients with recent symptomatic lacunar infarcts all confirmed on MRI, and showed that long-term dual antiplatelet therapy with clopidogrel and aspirin did not reduce the risk of recurrent stroke but did significantly increase the risk of bleeding and death (693)
Interestingly, Bex treatment induced APOE and ABCA1 expression in murine brain capillary endothelial cells (mBCEC) in 3xTg AD mice
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