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[DOI] [PMC free article] [PubMed] [Google Scholar] Lieberherr D, Wagner U., Dubuis P.H., Metraux J.P., Mauch F

e) Parkinsons Disease Increased oxidative stress can damage dopaminergic neurons in the substantia nigra, leading to the characteristic symptoms of Parkinsons disease

Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a key transcription factor upregulating the antioxidant response element (ARE)-mediated expression of antioxidant and detoxifying enzymes, and the Nrf2-antioxidant pathway is critical in host defense against acute lung injury (ALI) 24