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Clinical markers of progression Older age, male sex, higher baseline motor scores and worse baseline cognition have all been linked to worse motor and cognitive outcomes at longitudinal follow-up 141,182,194,195,196 and have been integrated with sleep disorder, presence of depression and various genetic, imaging or CSF biomarkers into clinical predictive scores 182,196

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Ferroptosis represents a novel form of programmed cell death, distinguished by its reliance on iron-mediated lipid peroxidation as a pivotal mechanism leading to cell death [30]

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