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[41] Epigenetic modifications like demethylation of the promoter and acetylation of histone 3 have been shown to sustain the overexpression of p66Shc, an essential source of mitochondrial ROS

[6] Therefore, boosting or maintaining glutathione levels could help prevent the oxidative stress that leads to some health issues

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In a second study, 18 hypertensive smokers whose blood pressures were not controlled with ACE inhibitor monotherapy (enalapril or captopril) were given adjunct treatment with NAC, 1.8 g/day for 21 days, resulting in a decrease in 24 h ambulatory and daytime systolic and diastolic blood pressures (39)