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Summary: N-acetylcysteine (NAC) has four possible modes of action: Increased glutathione availability Direct binding of NAPQI Provision of inorganic sulfate Reduction of NAPQI back to paracetamol Traditional Three-Bag Regimen : Adult dosing: Give 150 mg/kg NAC diluted in 200 ml of 5% dextrose IV over 15-60 minutes
Spicka I, Moreau P, Martin TG, et al
doi: 10.1093/aje/kwv095 107 HetzC.ZhangK.KaufmanR
