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VIP/PACAP and cancers Human cancers including bladder, breast, colon, liver, lung, pancreatic, prostate, thyroid, and uterine cancers often overexpress VPAC1, whereas VPAC2 is limited in stromal tumors such as gastric leiomyomas, sarcomas, and neuroendocrine tumors 109
And I think some animal studies by that same group have shown that
For GHRs, the size difference is essentially linked to insertions in the Trx domain ( ca 35 amino acids between the active site motif and the cis -Pro, i.e
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