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Aging, Longevity and Mitochondrial Function Glutathione deficiency is a hallmark of aging that contributes to age-related metabolic decline and mitochondrial dysfunction

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doi: 10.1186/s12888-018-1942-1

Further investigation of the pathways involving GSH is expected to bring important insights into cancer (patho)physiology understanding ( Besides ATF4, another transcription factor that regulates xCT expression is the nuclear factor erythroid 2-related factor 2 (NRF2) via the antioxidant response element (ARE) present in the promoter region of xCT gene (40, 41)