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Nitrosamines or their precursors occur in a wide variety of foods and manufactured and natural products, such as agricultural chemicals, tobacco, detergents, rust inhibitors, cutting fluids, rubber additives, solvents, drugs, plastics, tanned leather products, textiles, and cosmetics (ATSDR 1989a)

demonstrated that lycorine triggers programmed necrosis in the ARH-77 multiple myeloma cell line via G 1 arrest, mitochondrial dysfunction, ROS-mediated oxidative stress, ATP depletion, and DNA damage, offering a necroptosis-like mechanism to combat apoptosis-resistant MM cells (34)

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In the context of CIRS, where low VEGF is often paralleled by fatigue and cognitive dulling, Rhodiolas dual impact on perfusion and mitochondrial function may offer a multipronged benefit