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Description
In APCs, CD80 interacts with PD-L1 in cis to disrupt PD-L1/PD-1 interaction between APCs and T cells, limiting the PD-1 coinhibitory signal, while promoting CD28/CD80 interactions and enhancing T cell activation (213)
[DOI] [PubMed] [Google Scholar] 82.Duzel A, Vlainic J, Antunovic M, Malekinusic D, Vrdoljak B, Samara M, et al
This receptor plays a central role in signaling endothelial cells to proliferate, migrate, and form new vessel structures
The net effect of Akt activation is a shift toward anabolism: more protein synthesis and less protein breakdown
