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Pharmacological Reviews, 59(2), 151184

Prohibitin in mitochondrial function Inside mitochondria, prohibitin complexes (formed by PHB1 and PHB2 subunits) act as molecular chaperones that help maintain mitochondrial structure and function

Its compact molecular architecture enables selective binding to the NNMT active site, allowing researchers to study dose-dependent enzyme inhibition in vitro and in preclinical models