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Clinical Evidence 2026 Update: Phase 3 TRIUMPH Data In December 2025, Eli Lilly reported the first successful Phase 3 readout for retatrutide (LY3437943) from the TRIUMPH-4 trial

Choosing the Right Injection Site Ideal SubQ Sites: Abdomen 2 inches away from the navel Thighs front of the upper leg Upper arms back of the upper arm (best if done by someone else) Rotate Sites Consistently: Using a rotation chart prevents repeated trauma and allows the tissue to recover

Learn more Semaglutide is a GLP-1 (glucagon-like-peptide-1) receptor agonist and is FDA approved for weight loss

Those modifications are why semaglutide works as a once-weekly injection rather than requiring multiple daily doses