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In this setting, seizure freedom may not be obtained, and more obtainable goals should be established (e.g., decrease in the number of seizures and minimized drug adverse effects)

NAC : NAC is generally well tolerated, but may cause similar side effects like gastrointestinal issues (e.g., nausea, vomiting, or diarrhea)

The stimulation of the 7nAChR has been shown to exert anti-inflammatory effects by inhibiting cytokine production and release, such as TNF-, which is neurotoxic, by microglia (97, 98)

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