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Rinninella et al., 2019
Thus, MASLD patients contrast to patients that have progressed to liver cirrhosis, as these patients are more susceptible to developing sarcopenia, a chronic catabolic state with increased energy expenditure, decreased appetite, low protein synthesis, and the development of ascites or portosystemic shunts that contribute to muscle atrophy (130)
10.1016/j.pharmthera.2007.10.001 24
A pharmacokinetic-pharmacodynamic model for intrathecal baclofen in patients with severe spasticity
