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Karikari, Isaac O
When [ 13 C 5 ]KIV was used as substrate, the TCA cycle intermediates were now clearly labeled, but MMA hepatocytes had significantly lower incorporation of 13 C into these intermediates under all experimental conditions compared with healthy hepatocytes (Figure 4, BE)
Further, carnitine binds acyl residues resulting from the intermediary metabolism of amino acids (branched-chain especially) to aid their elimination, and it regulates the acyl-CoA/CoA ratio, thereby controlling the activity of several mitochondrial enzymes
elegans under both diabesity and standard conditions
