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Immortalization involves modifying somatic cells to enable indefinite selfrenewal by introducing telomerase or altering genes that regulate the cell cycle and prevent telomere shortening (De Bardet et al

As expected, the GSH levels were reduced by 100 M of hydrogen peroxide but enhancing network activity with blockers of GABA A receptors (bicuculine) and KCNA channels (4-AP) attenuated this effect

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