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Symptom Monitoring: Even though serious adverse events did not occur in trials, individual monitoring for headache, gastrointestinal symptoms, or unusual effects allows for early detection of tolerability issues and appropriate management adjustments

Front Neurosci 13:127 Ziff OJ, Neeves J, Mitchell J et al (2023) Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology
Sci Rep 7(1):10718 Yamamoto K, Yoshida H, Kokame K, Kaufman RJ, Mori K (2004) Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE UPRE and ERSE-II

It has been an amazing journey watching the growth of the clinic and what is has become today
