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Mecobalamin may interfere with the effectiveness of certain chemotherapy drugs, especially those used to treat cancers such as leukemia, affecting their absorption or efficacy

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Gastric or bariatric surgery : Patients who have undergone weight loss surgeries such as gastric or bariatric surgery may experience B12 deficiency due to the unavailability of intrinsic factor after gastric or intestinal resection

Depending on the reason for the deficiency, the individual may need to take vitamin B12 treatment for their whole lives or until their vitamin B12 levels return to normal