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doi:10.1001/archneur.1992.00530300089014

lack of placebo controls for many studies, resulting in a likely over-estimation of efficacy

In conclusion, this study demonstrated that intra-articular injections of AOD9604 improved cartilage health and functional recovery in a rabbit OA model

Eleven of the twelve patients (91.6%) had a significant improvement in knee pain, and, in most of them, the improvement lasted between 6 months and 1 year and they enjoyed improved sleep as well as mobility when knee pain decreased