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(Reference Nichole, Ying, Marian and Fereidoon35,Reference Feng, Ding, Lin and Chen36) Serum enzymes (ALT, AST, and ALP) were significantly elevated in cadmium-exposed rats, indicating liver damage induced by cadmium

C-reactive protein reflects oxidative stress (Moreira-Rosrio et al., 2021) and is a marker for LC, CFS, and vitamin D deficiency

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In vitro and in vivo models, knockout or inhibition of GPX4 can rapidly induce severe lipid peroxidation, mitochondrial rupture, and typical ferroptosis phenotypes in chondrocytes, further reinforcing its core role in maintaining joint homeostasis (Sun S