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Males exhibit greater deficits in finger dexterity as measured using the 9 hole peg test ( Male sex is also a predictive factor for having a shorter time to reaching a disability milestone of expanded disability status scale (EDSS)3 and EDSS6 ( Individuals with MS also experience cognitive deficits including reductions in verbal and non-verbal memory, information processing speed, attention, and executive functioning (36)

Genetically, ferroptosis involves various gene regulatory mechanisms, primarily related to genetic alterations in iron homeostasis and lipid peroxide metabolism during ferroptosis [15]