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Future research may focus on further exploring the structureactivity relationship of NRF2 activators, identifying more effective and selective compounds, and studying the potential therapeutic applications of these activators in different disease models

Similar to the reversible ADP-ribosylation of proteins and DNA, the ADP-ribosylation of RNA can also be efficiently reversed by several cellular hydrolases including TARG1, MACROD1-2, PARG, NUDT16 and ARH3 viruses

Moreover, phosphorylation of other residues localized at the C-terminal region of the protein has been associated with these diseases [33]

The search process is shown in Fig