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If OI are more opioid-tolerant than NIO, we hypothesize they would: (1) under controlled conditions, exhibit attenuated responses to a standard opioid challenge, as found in a preliminary study [46], (2) in an outpatient setting, use higher doses of illicit opioids to overcome this tolerance, (3) require higher buprenorphine concentrations to deter illicit opioid use, and (4) tolerate such higher buprenorphine concentrations without a clinically significant increase in safety problems (i.e., larger therapeutic window)

Policing in this rough-and-tumble political town meant dealing with nightly squatters and petty thieves, but in 1879, it involved the investigation of one of the most ambitious murder plots ever recorded

Gajra, A

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