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Most of these acetyl groups are further oxidized in the mitochondrias Krebs cycle, but some are needed in the cytosol for producing other important metabolites

ATF3 upregulates heme oxygenase 1 that is integral in controlling internal iron levels conducive to lipid peroxidation (118)
CysLT1 antagonists, including montelukast, pranlukast, and zafirlukast, are used worldwide for the treatment of asthma

doi: 10.1016/j.redox.2019.101255 379 WeinbergSESenaLAChandelNS
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