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Mechanistically, GSTM2 interacted with ASK1 and suppressed its phosphorylation and the activation of subsequent downstream p38-JNK signalling

Cochlear hair cells possess limited intrinsic antioxidant capacity, with lower glutathione (GSH) concentrations and reduced catalase activity relative to many other cell types, and a restricted ability to regenerate reduced GSH from oxidized forms (Schacht et al., 2012

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In addition, myelin structure becomes dysregulated particularly in the white matter, with myelin thickening, outfoldings, unravelling, enlargement of inner tongues 90,91,92