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Energy homeostasis regulation In sports medicine, l-carnitine is used to inhibit glycolysis by suppressing pyruvate dehydrogenase ( Reference Constantin-Teodosiu, Carlin and Cederblad 66 ) , or phosphofructokinase activity ( Reference Eizadi, Bakhshi and Abrifam 67 ) , which reduces exercise-associated lactate accumulation ( Reference Siliprandi, Di Lisa and Pieralisi 68 Reference Vecchiet, Di Lisa and Pieralisi 70 ) , and delays the development of fatigue ( Reference Brass 71 , Reference Karlic and Lohninger 72 )