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its activity is diminished in cellular assays owing to its swift degradation to adenosine and Hcy by SAH hydrolase ( Streptomyces , serves as a SAM-mimicking methyltransferase inhibitor
It works synergistically with folate in DNA synthesis and homocysteine metabolism
[7] [12] Women with pernicious anaemia , an autoimmune condition affecting B12 absorption, require ongoing B12 replacement therapy throughout pregnancy
However, in some cases, high doses can cause mild symptoms
