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The ET(A)-Receptor Antagonist LU 135252 Prevents the progression of established pulmonary hypertension induced by monocrotaline in rats

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doi: 10.1517/14712598.7.9.1287 83 ShafqatAAbdul RabSAmmarOAl SalamehSAlkhudairiAKashirJet al

In colorectal cancer, a high density of M2-like macrophages within the tumor stroma strongly correlates with reduced cancer-specific survival, while an elevated M1/M2 ratio indicates better prognosis, suggesting polarization status rather than overall density serves as a critical determinant of disease outcome ( Macrophage polarization represents a core manifestation of functional plasticity, and its conceptual framework has evolved from the traditional M1/M2 dichotomy toward a spectrum theory