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10.1016/j.biopha.2016.11.047 [DOI] [PubMed] [Google Scholar] Bozorgi A., Khazaei M., Khazaei M
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Conditional cell-penetrating peptide exposure as selective nanoparticle uptake signal
However, high doses or prolonged use of MTX can lead to liver injury through various mechanisms, including inflammatory responses, oxidative stress, mitochondrial dysfunction, and metabolic disturbances, making hepatotoxicity one of the main side effects in clinical applications (Shetty et al., 2017)
