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Some of the most common causes include: Mental fatigue Anemia (iron deficiency) Chronic conditions, like heart disease , thyroid disease, sleep disorders, diabetes, or arthritis Medications, such as sedatives High use of alcohol or drugs Autoimmune conditions Malnutrition Chronic fatigue syndrome No matter the cause, fatigue impacts daily life

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18 Further study shows that CPTIC is induced by AMPK activation under hypoxia and a p53AMPKCPTIC axis evoked in response to metabolic stress has also been implicated