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Although functional data supporting a trans- inhibition model were obtained when constitutive activation of JAK2 was shown with a JAK2 construct where the pseudokinase and KDs were swapped and this construct showed significant cytokine-independent activation only in the presence of wild-type JAK2 (51)

Growth Hormone Research Society Workshop Summary: Consensus guidelines for recombinant human growth hormone therapy in critically ill adults. Crit Care Med

Stroud, 196

Agonist-induced conformational changes in the G-protein-coupling domain of the beta 2 adrenergic receptor
