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In turn, the impairment in -oxidation can shift the metabolism of VPA toward predominantly peroxisomal -oxidation, resulting in excessive production and accumulation of -oxidation products, including 4-en-VPA a metabolite that is incriminated in VPA-induced hepatotoxicity

Mitochondrial trifunctional protein (MTP) defects are disorders of mitochondrial fatty acid -oxidation pathway of which progressive pigment chorioretinopathy is a long-term complication [164]

Zinc is involved in cell division, DNA synthesis and the maintenance of normal testosterone levels in the blood

SCFA regulate cytokines such as TNF-, interleukin 6 (IL-6), and IL-10, which affect inflammation and immune cell activity