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Transforming growth factor-3 (TGF-3) exerts a protective effect on hippocampal neurons by binding to the TGF- type receptor I (TGF-RI), this neuroprotective effect is mediated by activation of the nuclear transcription factor 2 (Nrf-2)/Kelch-like ECH associated protein 1 (KEAP1)/hemo oxygenase 1 (HO-1) pathway, which strengthens the antioxidant defense and supports neuronal survival [44]
10.3390/ijms17020133 [DOI] [PMC free article] [PubMed] [Google Scholar] Huang X., Cheng Z., Su Q., Zhu X., Wang Q., Chen R., et al
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In situations where this compensatory effect is efficient, ROS levels may appear normal even under prooxidant conditions
