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Smad Proteins: Smads are key intracellular signaling molecules that relay the TGF- signal from the cell membrane to the nucleus
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A 2020 review of case reports found that self-administered coffee enemas caused adverse effects such as: abdominal pain bloody stool rectal pain or burning proctocolitis, or inflammation of the rectal lining colitis, or inflammation of the colon The review also noted three deaths following coffee enema
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