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Genetic damage in Parkin, PTEN Induced Kinase 1 (PINK1) genes and in the DJ-1 protein (which acts as a neuroprotective redox sensor) result in decreased activity of mitochondrial complex I enzyme and decreased adenosine triphosphate (ATP) production (Greco et al., 2023

However, it is crucial to emphasize that all data supporting this rationale derive from in vitro cell culture studies, in vivo animal experiments in rats and swine, and mechanistic extrapolation from established neuroendocrine physiology

In cephalopods, however, sigma GSTs are lens S -crystallins [3], giving an indication of the functional diversity of these proteins