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doi: 10.3390/metabo12040352 99 MikiYTaketomiYKidoguchiYYamamotoKMuramatsuKNishitoYet al

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Molecular docking and molecular dynamics studies revealed that key target proteins like serine/threonine-protein kinase (AKT1), peroxisome proliferator-activated receptor alpha (PPARA), and peroxisome proliferator-activated receptor gamma (PPARG), exhibited strong binding affinity and stable interactions with multiple phytocomponents present in DME

193 Additional evidence suggests that reshaping the gut microbiome of high-fat diet (HFD)-fed obese mice with dietary fibers successfully mitigated the cognitive and social impairments of their offspring by alleviating the microglial maturation defects