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First, the effect is enzymatic and cumulative you are shifting a metabolic set-point over days and weeks, not triggering an acute hormonal event, which is why steady daily exposure matters more than any single large dose

(2010) Evaluation of a therapeutic diet for feline degenerative joint disease., Journal of veterinary internal medicine, 24(3), pp

doi: 10.1111/acel.12601

VEGF pathway synergy: Works synergistically with VEGF promoting physiological angiogenesis