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When adapted to climate change, a distribution bottleneck can arise, such as (1) the emergence of new suitable areas, (2) the shrinking of existing habitats, and (3) the inability of species to reach these areas due to barriers

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NAD + decline seems to be the major feature also in progeria syndromes of accelerated aging, and the administration of NAD + precursors such as NR or NMN offer therapeutic strategies to improve health during aging and progeria comorbidities