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[2] In DIO mice, 5-Amino-1MQ was reported to reduce body weight and white adipose mass and to lower plasma cholesterol, without a measured change in food intake

In these studies, AOD-9604 administered via intraperitoneal injection produced significant fat mass reduction without changes in food intake or lean body mass

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When NNMT is overactive, less nicotinamide is available for recycling, and cellular NAD+ levels fall