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However, acylcarnitine was shown to reduce the levels of specific claudin proteins and alter the barrier function of tight junctions in Caco-2 cell monolayers and is should be cautiously considered for people who already have intestinal barrier problems [237]

The magnitude of LDL lowering associated with statin treatment varies widely among individuals, but once a patient is on a statin, the doubling of the statin dose produces an ~6% further reduction in the level of plasma LDL-C

While L-carnitine supplementation may aid in weight loss, improve brain function, and benefit heart health and type 2 diabetes, the evidence is mixed

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