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54 56 Studies of ALDH2*2 and CRC have yielded inconsistent results

Some Another study in healthy adults showed that supplementing with a multivitamin containing high levels of B-complex vitamins for 90 days reduced negative mood symptoms

The New England journal of medicine 338 , 209216, (1998)

It's a documented, dose-dependent, reproducible phenomenon that shows up in every controlled study of GH physiology
