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Histamine H Receptor Antagonist (H 2 RA)/Proton Pump Inhibitor (PPI) Induced Vitamin B 12 Depletion Literature suggests that drugs which suppress stomach acid production such as PPIs 159163 and HRAs 164167 interfere with vitamin B 12 absorption, by reducing dietary B12 release from food proteins

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Image credits: dodotone/Adobe Stock (Not the actual photo) Applegate has said she initially noticed subtle symptoms, including problems with balance, numbness in her limbs, and subtle tingling in her toes, but attributed them to fatigue before learning the devastating truth