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doi: 10.1111/and.13898

[103] found that the mitochondrial levels of SAM were reduced in DS, suggesting that impairment of the methyl cycle affected mitochondrial methyl availability in DS

As increasing evidences show diabetes mellitus as a distinct comorbidity leading to acute respiratory distress syndrome and increased mortality in patients with COVID-19 having cytokine storm, thymulin, and PRDX6 might serve as a supporting anti-inflammatory treatment in the therapy of COVID 19 in diabetic patients