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The clinical manifestations can vary from multi-organ failure in the neonate with a fatal outcome to late-onset symptoms associated with significant disabilities

5.Could you provide a medical note for my child's school explaining that the odor is a medication side effect and not a hygiene issue

Metabolic decompensation can also result in elevated liver aminotransferases, hyperammonemia or chronic myopathy [98]

Molecular and biochemical aspects of the PD-1 checkpoint pathway
