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Contrary to the reported positive effects of p53 and ATM on the oxidative PPP, other reports suggest that p53 inhibits the PPP, as the loss of p53 increases NADPH production 45

2018;283(5):489-499 Calderon-Larranaga A

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This is where the sensory nerves travel (carrying migraine/headache/pain signals to the brain) and neuromuscular junctions lie (where the nerves that innervate and control the muscles enter the muscle)